Motif ID: TFAP2{A,C}.p2

Z-value: 4.823


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10523424-0.486.1e-02Click!
TFAP2Cchr20_+_546377140.019.6e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_63292688 6.832 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr16_-_87535106 6.006 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr9_+_136673534 5.786 COL5A1
collagen, type V, alpha 1
chr2_+_96845704 5.667 NM_017623
NM_199078
CNNM3

cyclin M3

chr1_+_33494745 4.555 NM_152493
ZNF362
zinc finger protein 362
chr1_-_39815002 4.211 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr11_+_62136788 3.923 NM_000327
ROM1
retinal outer segment membrane protein 1
chr3_-_124650081 3.854 NM_183357
ADCY5
adenylate cyclase 5
chr17_+_17525571 3.827


chr9_+_136673464 3.764 NM_000093
COL5A1
collagen, type V, alpha 1
chr1_-_39815048 3.673 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr17_-_19711580 3.607 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr6_+_157141565 3.339 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr15_+_66658626 3.309 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr5_-_138758783 3.309 NM_001161546
LOC389333
hypothetical protein LOC389333
chr2_+_171280944 3.180 SP5
Sp5 transcription factor
chr8_-_80842452 3.115 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr9_-_139316523 3.108 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr17_+_17525497 3.106 NM_030665
RAI1
retinoic acid induced 1
chr17_-_59131194 3.086 LIMD2
LIM domain containing 2
chr1_+_226937732 3.061 RHOU
ras homolog gene family, member U
chr16_+_19087035 3.003 NM_016524
SYT17
synaptotagmin XVII
chr1_-_39815106 2.997 NM_001135653
NM_001135654
NM_003819
PABPC4


poly(A) binding protein, cytoplasmic 4 (inducible form)


chr6_+_107917965 2.980 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr7_+_99919485 2.960 NM_173564
C7orf51
chromosome 7 open reading frame 51
chr8_+_74369647 2.944 NM_172037
RDH10
retinol dehydrogenase 10 (all-trans)
chr17_+_52026058 2.886 NM_005450
NOG
noggin
chr10_-_76829857 2.883 ZNF503
zinc finger protein 503
chr20_-_43953036 2.872 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr9_-_93751900 2.859 NM_004560
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr2_-_158440587 2.853 NM_001111067
ACVR1
activin A receptor, type I
chr3_+_50167851 2.835 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr1_-_32574185 2.827 NM_023009
MARCKSL1
MARCKS-like 1
chr11_-_60819110 2.805 VWCE
von Willebrand factor C and EGF domains
chr4_+_110574274 2.776 SEC24B
SEC24 family, member B (S. cerevisiae)
chr6_+_1556543 2.776 FOXC1
forkhead box C1
chr12_+_108636569 2.748 NM_032829
C12orf34
chromosome 12 open reading frame 34
chr10_-_69836912 2.744 NM_017987
NM_001042417
RUFY2

RUN and FYVE domain containing 2

chr1_-_39814659 2.686 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr15_+_97462675 2.668 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chr2_-_197165495 2.641 NM_020760
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr4_+_42094612 2.625 NM_001080505
SHISA3
shisa homolog 3 (Xenopus laevis)
chr8_-_93184629 2.618 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr20_+_43952997 2.603 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr10_+_104394185 2.515 NM_030912
TRIM8
tripartite motif containing 8
chr1_+_153560351 2.480 NM_001105205
RUSC1
RUN and SH3 domain containing 1
chrX_+_149282097 2.467 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr4_-_25473528 2.438 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr1_-_153560532 2.427 NM_001039517
C1orf104
chromosome 1 open reading frame 104
chr6_+_43247179 2.425 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr10_+_134201262 2.374 NM_005539
INPP5A
inositol polyphosphate-5-phosphatase, 40kDa
chr3_+_49002774 2.366 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr17_-_71385651 2.362 TRIM47
tripartite motif containing 47
chr7_-_148825760 2.360 ZNF746
zinc finger protein 746
chr13_-_76358433 2.349 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr6_+_43247168 2.327 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr1_+_108904191 2.321 FAM102B
family with sequence similarity 102, member B
chr13_-_76358370 2.292 KCTD12
potassium channel tetramerisation domain containing 12
chr4_+_110574420 2.274 SEC24B
SEC24 family, member B (S. cerevisiae)
chr2_-_39040981 2.274 LOC375196
hypothetical LOC375196
chr2_+_36436873 2.264 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr6_-_132764257 2.261 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr5_-_14924555 2.259 NM_054027
ANKH
ankylosis, progressive homolog (mouse)
chr2_-_45090025 2.242 NM_016932
SIX2
SIX homeobox 2
chr19_+_1200882 2.231 MIDN
midnolin
chr14_+_68796621 2.159 GALNTL1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
chr1_+_22909916 2.146 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr10_+_116571485 2.144 NM_001135051
NM_020940
FAM160B1

family with sequence similarity 160, member B1

chr9_-_88751923 2.142 NM_002048
GAS1
growth arrest-specific 1
chr8_-_144583718 2.136 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr14_+_57932396 2.130 NM_207377
TOMM20L
translocase of outer mitochondrial membrane 20 homolog (yeast)-like
chr22_+_29361672 2.128 NM_001001479
SLC35E4
solute carrier family 35, member E4
chr17_-_60346042 2.117 LRRC37A3
leucine rich repeat containing 37, member A3
chr2_-_25418856 2.112 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr2_-_25418960 2.098 NM_175629
NM_175630
DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha

chr1_-_32176562 2.090 NM_080391
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr16_+_51722285 2.088 CHD9
chromodomain helicase DNA binding protein 9
chr15_-_50608296 2.085 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr7_+_55999559 2.084 NM_001483
GBAS
glioblastoma amplified sequence
chr8_-_97242119 2.077 NM_001001557
GDF6
growth differentiation factor 6
chr2_-_25418819 2.064 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr2_+_176695658 2.060 NM_014213
HOXD9
homeobox D9
chr2_-_96899326 2.056 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr11_-_62136778 2.046 NM_153265
EML3
echinoderm microtubule associated protein like 3
chr12_-_122201237 2.039 PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr20_-_4177519 2.037 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr6_+_157722467 2.030 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr1_-_19155360 2.011 NM_001136265
IFFO2
intermediate filament family orphan 2
chr17_-_60345364 2.005 NM_199340
LRRC37A3
leucine rich repeat containing 37, member A3
chr3_+_44878380 1.989 NM_144638
TMEM42
transmembrane protein 42
chr4_+_7245218 1.985 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr6_-_128883125 1.984 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr13_-_101366995 1.984 NM_004115
FGF14
fibroblast growth factor 14
chr2_-_96899396 1.977 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr15_+_64782468 1.970 SMAD6
SMAD family member 6
chr14_-_104705753 1.969 JAG2
jagged 2
chr10_+_29006425 1.967 NM_012342
BAMBI
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr17_-_59131210 1.962 NM_030576
LIMD2
LIM domain containing 2
chr1_+_89871281 1.960 LRRC8C
leucine rich repeat containing 8 family, member C
chr6_+_151229003 1.957 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr7_-_120823556 1.955 FAM3C
family with sequence similarity 3, member C
chr4_-_110574363 1.947 1/2-SBSRNA4
lncRNA_BC009800
chr8_+_107351519 1.932 NM_001198533
NM_018002
LOC346887
OXR1

similar to solute carrier family 16 (monocarboxylic acid transporters), member 14
oxidation resistance 1

chr17_+_72376022 1.925 NM_144677
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr14_+_68796433 1.917 NM_001168368
NM_020692
GALNTL1

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1

chr7_-_106088565 1.902 NM_175884
FLJ36031
hypothetical protein FLJ36031
chr1_-_94147574 1.889 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr9_+_130222943 1.883 CERCAM
cerebral endothelial cell adhesion molecule
chr11_+_109469296 1.880 NM_033390
ZC3H12C
zinc finger CCCH-type containing 12C
chr2_+_85834111 1.879 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr8_-_11096257 1.878 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr1_-_6162669 1.874 NM_015557
CHD5
chromodomain helicase DNA binding protein 5
chr1_-_94147537 1.856 GCLM
glutamate-cysteine ligase, modifier subunit
chr16_+_55684030 1.844 CPNE2
copine II
chr7_-_138316393 1.830 NM_001164665
NM_020910
KIAA1549

KIAA1549

chr16_-_4263056 1.824 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr17_+_34140030 1.802 NM_001136498
CISD3
CDGSH iron sulfur domain 3
chr3_-_129689394 1.800 NM_001145662
GATA2
GATA binding protein 2
chr22_-_30071761 1.795 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr1_-_32002222 1.778 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr14_-_30746431 1.776 NM_015382
HECTD1
HECT domain containing 1
chr15_+_65145248 1.771 NM_005902
SMAD3
SMAD family member 3
chr2_-_225615556 1.761 NM_014689
DOCK10
dedicator of cytokinesis 10
chr3_-_45242072 1.759 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr1_-_32176475 1.758 PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr12_-_41164010 1.755 PRICKLE1
prickle homolog 1 (Drosophila)
chr7_+_72720093 1.755 NM_001077621
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr10_+_134060681 1.754 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr14_-_76677711 1.749 ZDHHC22
zinc finger, DHHC-type containing 22
chr1_-_222100226 1.746 TP53BP2
tumor protein p53 binding protein, 2
chr6_+_41148665 1.746 NM_002505
NM_021705
NFYA

nuclear transcription factor Y, alpha

chr9_+_137119334 1.743 OLFM1
olfactomedin 1
chr7_-_120823591 1.742 NM_001040020
NM_014888
FAM3C

family with sequence similarity 3, member C

chr11_+_74629597 1.736 NM_001195528
LOC441617
hypothetical LOC441617
chr14_+_99329198 1.735 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr16_+_55684031 1.731 CPNE2
copine II
chr12_+_6907646 1.728 NM_001940
ATN1
atrophin 1
chr17_+_45008473 1.727 NXPH3
neurexophilin 3
chr10_+_23768203 1.725 NM_001145373
OTUD1
OTU domain containing 1
chr20_+_60906605 1.724 NM_007346
OGFR
opioid growth factor receptor
chr9_+_115958051 1.719 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr11_+_19691397 1.716 NM_145117
NM_182964
NAV2

neuron navigator 2

chr6_+_41148691 1.713 NFYA
nuclear transcription factor Y, alpha
chr3_+_171558188 1.708 SKIL
SKI-like oncogene
chr9_+_99785493 1.706 ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr11_+_33235743 1.697 NM_001048200
NM_005734
HIPK3

homeodomain interacting protein kinase 3

chr17_+_15789147 1.690 ADORA2B
adenosine A2b receptor
chr21_-_31853160 1.686 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr4_+_110574376 1.678 NM_001042734
NM_006323
SEC24B

SEC24 family, member B (S. cerevisiae)

chr12_+_732349 1.670 NM_001184985
NM_014823
NM_018979
NM_213655
WNK1



WNK lysine deficient protein kinase 1



chr12_+_50104936 1.668 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr18_-_22382497 1.665 NM_001142730
KCTD1
potassium channel tetramerisation domain containing 1
chr4_+_186368277 1.662 NM_031953
SNX25
sorting nexin 25
chr22_+_30072739 1.660 FLJ20464
hypothetical protein FLJ20464
chr17_+_15788955 1.659 NM_000676
ADORA2B
adenosine A2b receptor
chr12_+_44409762 1.658 NM_152641
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chrX_-_154341451 1.657 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr6_+_43246897 1.655 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr9_+_133259330 1.652 PRRC2B
proline-rich coiled-coil 2B
chr20_+_6696744 1.644 NM_001200
BMP2
bone morphogenetic protein 2
chr16_-_55016872 1.643 NM_001144
AMFR
autocrine motility factor receptor
chr11_+_46256130 1.639 CREB3L1
cAMP responsive element binding protein 3-like 1
chr22_-_30071565 1.638 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr15_-_59308770 1.637 NM_134261
RORA
RAR-related orphan receptor A
chr4_-_170428768 1.637 NM_020870
SH3RF1
SH3 domain containing ring finger 1
chr8_+_1937711 1.633 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr12_-_122322117 1.632 NM_004642
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr18_-_44731078 1.629 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr1_-_1274618 1.629 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr21_+_32167175 1.616 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase
chr7_-_148825679 1.616 ZNF746
zinc finger protein 746
chr18_-_44730706 1.606 SMAD7
SMAD family member 7
chr7_+_72720256 1.603 VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr5_-_94646033 1.602 NM_024717
MCTP1
multiple C2 domains, transmembrane 1
chr2_-_38457934 1.602 NM_001135673
NM_022374
ATL2

atlastin GTPase 2

chr10_+_94439658 1.601 NM_002729
HHEX
hematopoietically expressed homeobox
chr17_+_45008175 1.601 NM_007225
NXPH3
neurexophilin 3
chr14_-_29466562 1.597 NM_002742
PRKD1
protein kinase D1
chr12_-_6535481 1.594 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr7_+_94374862 1.588 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr12_-_120389419 1.585 KDM2B
lysine (K)-specific demethylase 2B
chr11_-_65082208 1.580 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr11_+_915795 1.579 NM_012305
AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr19_-_43438818 1.576 PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr11_+_915874 1.575 AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr4_-_39655554 1.571 PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr19_+_12805747 1.571 MAST1
microtubule associated serine/threonine kinase 1
chr11_+_915899 1.569 AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr17_+_71097147 1.564 MYO15B
myosin XVB pseudogene
chr7_-_27136876 1.564 NM_002141
HOXA4
homeobox A4
chr9_+_128416542 1.563 NM_001174146
NM_001174147
NM_002316
LMX1B


LIM homeobox transcription factor 1, beta


chr8_+_37672427 1.557 NM_025069
ZNF703
zinc finger protein 703
chr9_-_76832844 1.550 C9orf41
chromosome 9 open reading frame 41
chr8_-_42028634 1.536 NM_001099412
NM_001099413
NM_006766
MYST3


MYST histone acetyltransferase (monocytic leukemia) 3


chr5_-_171643399 1.528 NM_152277
UBTD2
ubiquitin domain containing 2
chr8_-_8788149 1.526 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr3_+_31549123 1.520 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr16_+_55683940 1.518 NM_152727
CPNE2
copine II
chr15_+_90198031 1.516 SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr15_+_79080341 1.515 NM_022566
MESDC1
mesoderm development candidate 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 5.16e-22 GO:0009987 cellular process
1.11 1.28e-14 GO:0044237 cellular metabolic process
1.16 3.97e-14 GO:0071840 cellular component organization or biogenesis
1.17 4.38e-14 GO:0016043 cellular component organization
1.10 2.93e-13 GO:0008152 metabolic process
1.14 6.23e-13 GO:0044260 cellular macromolecule metabolic process
1.17 1.05e-10 GO:0071842 cellular component organization at cellular level
1.17 1.06e-10 GO:0071841 cellular component organization or biogenesis at cellular level
1.10 2.88e-10 GO:0044238 primary metabolic process
1.18 6.81e-09 GO:0048523 negative regulation of cellular process
1.26 8.25e-09 GO:0007049 cell cycle
1.08 1.24e-08 GO:0065007 biological regulation
1.08 1.59e-08 GO:0050794 regulation of cellular process
1.08 1.71e-08 GO:0050789 regulation of biological process
1.11 2.08e-08 GO:0043170 macromolecule metabolic process
1.16 8.60e-08 GO:0048519 negative regulation of biological process
1.20 3.93e-07 GO:0007399 nervous system development
1.14 4.94e-07 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.13 5.19e-07 GO:0034641 cellular nitrogen compound metabolic process
1.19 1.17e-06 GO:0006996 organelle organization
1.42 2.23e-06 GO:0051325 interphase
1.12 2.97e-06 GO:0006807 nitrogen compound metabolic process
1.14 2.98e-06 GO:0044267 cellular protein metabolic process
1.19 4.69e-06 GO:0009966 regulation of signal transduction
1.29 5.78e-06 GO:0051726 regulation of cell cycle
1.25 9.56e-06 GO:0022402 cell cycle process
1.41 1.33e-05 GO:0051329 interphase of mitotic cell cycle
1.14 1.43e-05 GO:0048522 positive regulation of cellular process
1.17 1.52e-05 GO:0023051 regulation of signaling
1.23 1.85e-05 GO:0048468 cell development
1.11 1.91e-05 GO:0051179 localization
1.29 2.02e-05 GO:0000278 mitotic cell cycle
1.24 4.31e-05 GO:0051128 regulation of cellular component organization
1.14 4.40e-05 GO:0090304 nucleic acid metabolic process
1.22 1.62e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.23 1.73e-04 GO:0048699 generation of neurons
1.30 1.90e-04 GO:0000904 cell morphogenesis involved in differentiation
1.25 3.79e-04 GO:0022403 cell cycle phase
1.15 4.23e-04 GO:0006464 protein modification process
1.21 4.29e-04 GO:0022008 neurogenesis
1.20 4.51e-04 GO:0009892 negative regulation of metabolic process
1.12 4.77e-04 GO:0048518 positive regulation of biological process
1.25 5.29e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.21 1.26e-03 GO:0031324 negative regulation of cellular metabolic process
1.27 1.35e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.13 1.95e-03 GO:0043412 macromolecule modification
1.09 2.29e-03 GO:0032502 developmental process
1.09 2.30e-03 GO:0031323 regulation of cellular metabolic process
1.10 2.84e-03 GO:0019538 protein metabolic process
1.24 2.90e-03 GO:0032989 cellular component morphogenesis
1.17 4.14e-03 GO:0044085 cellular component biogenesis
1.10 4.30e-03 GO:0051234 establishment of localization
1.09 4.68e-03 GO:0019222 regulation of metabolic process
1.18 5.01e-03 GO:0022607 cellular component assembly
1.17 5.59e-03 GO:0044248 cellular catabolic process
1.24 5.90e-03 GO:0000902 cell morphogenesis
1.16 5.91e-03 GO:0051641 cellular localization
1.18 6.80e-03 GO:0010941 regulation of cell death
1.27 9.36e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.18 9.51e-03 GO:0043067 regulation of programmed cell death
1.19 9.98e-03 GO:0016265 death
1.18 1.05e-02 GO:0032268 regulation of cellular protein metabolic process
1.21 1.28e-02 GO:0030182 neuron differentiation
1.30 1.44e-02 GO:0010564 regulation of cell cycle process
1.19 1.48e-02 GO:0008219 cell death
1.27 1.68e-02 GO:0007409 axonogenesis
1.10 1.70e-02 GO:0006810 transport
1.09 1.75e-02 GO:0007275 multicellular organismal development
1.11 1.81e-02 GO:0044249 cellular biosynthetic process
1.55 2.00e-02 GO:0030278 regulation of ossification
1.13 2.01e-02 GO:0016070 RNA metabolic process
1.23 2.08e-02 GO:0048666 neuron development
1.14 2.27e-02 GO:0065009 regulation of molecular function
1.29 2.30e-02 GO:0044419 interspecies interaction between organisms
1.21 2.30e-02 GO:0009790 embryo development
1.09 2.43e-02 GO:0048856 anatomical structure development
1.19 2.56e-02 GO:0031399 regulation of protein modification process
1.18 2.68e-02 GO:0050793 regulation of developmental process
1.12 2.71e-02 GO:0010467 gene expression
1.17 2.72e-02 GO:0042981 regulation of apoptosis
1.38 2.77e-02 GO:0044087 regulation of cellular component biogenesis
1.26 2.94e-02 GO:0048812 neuron projection morphogenesis
1.36 3.02e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.10 3.12e-02 GO:0009058 biosynthetic process
1.16 4.18e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.21 4.20e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.08 4.37e-02 GO:0080090 regulation of primary metabolic process
1.13 4.74e-02 GO:0034645 cellular macromolecule biosynthetic process
1.19 4.80e-02 GO:2000026 regulation of multicellular organismal development
1.16 4.83e-02 GO:0051246 regulation of protein metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 1.60e-34 GO:0044424 intracellular part
1.08 2.44e-34 GO:0005622 intracellular
1.11 2.01e-28 GO:0005737 cytoplasm
1.09 4.78e-23 GO:0043226 organelle
1.09 7.05e-23 GO:0043229 intracellular organelle
1.09 8.69e-21 GO:0043227 membrane-bounded organelle
1.09 1.23e-20 GO:0043231 intracellular membrane-bounded organelle
1.12 1.64e-17 GO:0044444 cytoplasmic part
1.12 1.95e-14 GO:0005634 nucleus
1.20 4.24e-13 GO:0005829 cytosol
1.11 8.49e-13 GO:0044446 intracellular organelle part
1.11 9.00e-13 GO:0044422 organelle part
1.18 8.65e-11 GO:0044428 nuclear part
1.03 3.79e-09 GO:0005623 cell
1.03 4.58e-09 GO:0044464 cell part
1.15 4.20e-07 GO:0031974 membrane-enclosed lumen
1.17 4.28e-07 GO:0031981 nuclear lumen
1.15 5.35e-07 GO:0070013 intracellular organelle lumen
1.13 5.86e-07 GO:0043228 non-membrane-bounded organelle
1.13 5.86e-07 GO:0043232 intracellular non-membrane-bounded organelle
1.14 1.33e-06 GO:0043233 organelle lumen
1.17 2.60e-06 GO:0012505 endomembrane system
1.15 1.43e-04 GO:0005856 cytoskeleton
1.16 2.68e-04 GO:0005654 nucleoplasm
1.09 7.13e-04 GO:0032991 macromolecular complex
1.10 8.90e-04 GO:0043234 protein complex
1.12 1.19e-03 GO:0031090 organelle membrane
1.44 3.57e-03 GO:0031965 nuclear membrane
1.19 6.54e-03 GO:0031967 organelle envelope
1.26 8.11e-03 GO:0043005 neuron projection
1.33 8.26e-03 GO:0005635 nuclear envelope
1.19 9.93e-03 GO:0015630 microtubule cytoskeleton
1.16 1.43e-02 GO:0005794 Golgi apparatus
1.18 1.61e-02 GO:0031975 envelope
1.67 1.85e-02 GO:0005793 ER-Golgi intermediate compartment

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 9.42e-30 GO:0005515 protein binding
1.06 2.89e-17 GO:0005488 binding
1.26 3.44e-06 GO:0019899 enzyme binding
1.08 6.24e-06 GO:0003824 catalytic activity
1.19 2.66e-04 GO:0030528 transcription regulator activity
1.12 2.67e-04 GO:0000166 nucleotide binding
1.24 1.68e-03 GO:0008092 cytoskeletal protein binding
1.12 5.55e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.12 5.72e-03 GO:0032553 ribonucleotide binding
1.12 5.72e-03 GO:0032555 purine ribonucleotide binding
1.12 6.47e-03 GO:0017076 purine nucleotide binding
1.25 9.25e-03 GO:0019904 protein domain specific binding
1.37 1.13e-02 GO:0010843 promoter binding
1.19 1.92e-02 GO:0043565 sequence-specific DNA binding
1.35 2.20e-02 GO:0000975 regulatory region DNA binding
1.35 2.20e-02 GO:0001067 regulatory region nucleic acid binding
1.35 2.20e-02 GO:0044212 transcription regulatory region DNA binding
1.23 3.11e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.23 3.49e-02 GO:0030695 GTPase regulator activity
1.12 3.52e-02 GO:0030554 adenyl nucleotide binding
1.12 3.85e-02 GO:0032559 adenyl ribonucleotide binding
1.12 4.90e-02 GO:0005524 ATP binding